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Lesson Seven: Obesogens

Module Two: The Evidence for Obesogens


Review

The following questions are meant to give you an idea of this module's main learning objectives.  If you feel comfortable answering the questions without reviewing your notes, then you are on your way to knowing the content of this module.

  • How do nuclear receptors (NRs) function in the cell?  How are they similar/different from other cell receptors?
  • What is the primary difference between the NRs RXR and PPAR-gamma?
  • How do the qualities of NR ligands enable EDCs to be a problem when it comes to lipid homeostasis?
  • What possible effects to EDC mimicking ligands have on lipid metabolism?
  • What possible outcomes do these effects produce?

Creative Thinking Challenges

  • Could/Should a drug be designed to block the ability of EDCs to bind to NRs? What other side effects might such a drug have?
  • Research the biochemical pathways that occur when a ligand binds to RXR and to PPAR-gamma. How are they similar? How are they different?

If you have completed this Review, and are ready to take the Quiz for this module, please click on the "Quiz" button in the menu on the right of this page. If you aren't taking this course for credit, or wish to skip the Quiz, then click the "Next" button below to go on to the next module.